Do not hesitate. Make sure you are EVZIO-Ready

In an opioid overdose, time matters

In 2017, there were 47,600 deaths due to opioids, and more than half of opioid overdoses occurred outside a medical setting.1 As those on the front line of emergencies, you know the importance of access to take-home naloxone. A majority of states have enacted Good Samaritan legislation that is supportive of administering aid for opioid-related overdoses, and some states even go as far as providing immunity for events leading up to assisting in such a crisis, reinforcing the importance and need for take-home naloxone.2

Anywhere opioids are present there may be a risk of opioid overdose.1,3-5

EVZIO—an auto-injector designed to be easy to use—provides simple, on-the-spot voice and visual guidance to help those most likely to be the first to witness an opioid overdose administer naloxone.1,6 EVZIO is not a substitute for emergency medical care. The use of EVZIO may result in symptoms of acute opioid withdrawal.

Take-home naloxone options available

Naloxone Delivery Device preference7

75% Preferred EVZIO
  • 70.5% preferred EVZIO
  • 25% preferred Narcan® Nasal Spray
  • 4.5% had no preference

Adult participants overall preferred EVZIO vs. NARCAN nasal spray (P<0.01) in a simulated opioid overdose usability study (N=44).


EVZIO is tested to withstand the rigors of use outside a hospital environment7

Extreme temperatures:

Tested up to 6 months as high as 104°F (40°C)

Crushing:

Withstands up to 300-pound force to the device

Chemical exposure:

Tested with window cleaner, soap, bleach, acetone, nail polish, hand sanitizer, stain remover liquid, and hydrogen peroxide

Liquid ingress:

Protects against water penetration (eg, heavy rainfall) and delivers its intended dose. Tested by exposing the auto-injector to falling drops of water at a rate of 1 mm/min for a 10-minute period

Always have EVZIO on hand—you never know when you will need it. Remember, do not leave EVZIO in your car because extreme temperatures can affect your device. A great place to keep EVZIO is in your pocket or in your bag.

Talk to your kaleo representative to learn more about EVZIO.

You also can call 1-855-77-EVZIO (1-855-773-8946) for more information about EVZIO.

Reference:

  1. Centers for Disease Control and Prevention. CDC Wonder: About multiple causes of death, 1999-2017. http://wonder.cdc.gov/mcd-icd10.html. Accessed January 28, 2019.
  2. National conference of state legislatures. Drug overdose immunity and good Samaritan laws. 2017. http://www.ncsl.org/research/civil-and-criminal-justice/drugoverdose-immunity-good-samaritan-laws.aspx. Accessed January 28, 2019.
  3. EVZIO [prescribing information]. Richmond, VA: kaleo, Inc.
  4. Substance Abuse and Mental Health Services Administration. SAMHSA Opioid Overdose Prevention Toolkit. HHS Publication No. (SMA) 16-4742. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2018.
  5. Federation of State Medical Boards. Guidelines for the chronic use of opioid analgesics. April 2017. https://www.fsmb.org/siteassets/advocacy/policies/opioid_guidelines_as_adopted_april-2017_final.pdf. Accessed January 25, 2019.
  6. Adams JM. Increasing naloxone awareness and use: The role of health care practitioners. JAMA. 2018;319(20):2073-2074.
  7. Data on file. Richmond, VA: kaleo, Inc.
  8. NARCAN [prescribing information]. Radnor, PA. Adapt Pharma, Inc. 2017.
  9. Raffa RB, Taylor R JR, Pergolizzie JV JR, Nalamachu S, Edwards ES, Edwards ET. Application of human factors engineering (HFE) to the design of a naloxone auto-injector for the treatment of opioid emergencies. Drug Deliv and Transl Res. 2017;(7):1-10.

INDICATION

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up.

EVZIO is safe and effective in children for known or suspected opioid overdose.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about EVZIO?

EVZIO is used to temporarily reverse the effects of opioid medicines. The medicine in EVZIO has no effect in people who are not taking opioid medicines. Always carry EVZIO with you in case of an opioid emergency.

Who should not use EVZIO?

Do not use EVZIO if you are allergic to naloxone hydrochloride or any of the ingredients in EVZIO.

What are the ingredients in EVZIO?

Active ingredient: naloxone hydrochloride
Inactive ingredients: sodium chloride, hydrochloric acid to adjust pH, and water

What should I tell my healthcare provider before using EVZIO?

Tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of EVZIO?

EVZIO may cause serious side effects, including:

Common side effects of EVZIO include dizziness and injection site redness.

These are not all of the possible side effects of EVZIO. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click for full Prescribing Information and Patient Information.

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond. EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up. EVZIO is safe and effective in children for known or suspected opioid overdose.

Important Safety Information

What is the most important information I should know about EVZIO?

EVZIO is used to temporarily reverse the effects of opioid medicines. The medicine in EVZIO has no effect in people who are not taking opioid medicines. Always carry EVZIO with you in case of an opioid emergency.

INDICATION

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up.

EVZIO is safe and effective in children for known or suspected opioid overdose.